Gene expression influences 3D folding of chromosomes by altering structure of the DNA helix, finds study

PHYSorg
Jan 31, 2024, 11:28 am119 pts
A collaborative study by the UTokyo-KI LINK program, headed by Camilla Björkegren from Karolinska Institutet, Kristian Jeppsson and Katsuhiko Shirahige from The University of Tokyo shows that a protein complex named Smc5/6 binds DNA structures called positive supercoils. These form when the chromosomal DNA…

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