From blood to brain: Delivering nucleic acid therapy to the CNS

ScienceDaily
Aug 12, 2021, 12:31 pm115 pts
Researchers have developed a drug delivery platform wherein heteroduplex oligonucleotide drugs conjugated with cholesterol are able to cross the blood-brain barrier and achieve therapeutic concentrations in the central nervous system even with intravenous or subcutaneous dosing. The ability to target gene…

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