Visualization of the first contact between the earliest reported human coronavirus and its human receptor molecule

PHYSorg
Mar 7, 2025, 11:10 am267 ptsTop
Coronavirus 229E is the earliest reported human coronavirus (hCoV-229E). Researchers used cryo-EM, glycoproteomics, and modeling to generate the atomic structure of a fully glycosylated and membrane-bound hCoV-229E spike protein bound to its host receptor, human aminopeptidase N (hAPN).

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Visualization of the first contact between the earliest reported human coronavirus and its human receptor molecule

PHYSorg

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