Scientists reveal mechanism of maternal protein Pramel15 in promoting DNA demethylation in mouse zygotes

PHYSorg
Sep 3, 2024, 10:56 am592 ptsHotTop
DNA methyltransferase 1 (DNMT1) is an important DNA methyltransferase that maintains DNA methylation. The retention of DNMT1 and its cofactor UHRF1 in the cytoplasm is considered a major reason for passive DNA demethylation in the oocyte and early embryonic development.

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