Dissecting caspase-2-mediated cell death: From intrinsic PIDDosome activation to chemical modulation

PHYSorg
Aug 26, 2024, 4:29 pm808 ptsInterestingTop
Caspase-2, an initiator caspase, plays a critical role in programmed cell death in response to certain cellular stresses. Its activation is facilitated by the PIDDosome, a multi-protein complex that assembles under conditions of genotoxic stress. Despite caspase-2's importance, the mechanisms through which it…

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