Structure-destabilizing mutations transform Bcl-2 from an antiapoptotic protein into a proapoptotic protein

PHYSorg
Oct 19, 2023, 10:09 am203 pts
Bcl-2 family proteins are highly conserved molecules that play a crucial role in regulating the release of apoptotic proteins from mitochondria. They possess Bcl-2 homology (BH) domains, which are characterized by both sequence and structural similarities, and are essential for their interactions and functions.

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