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Aug 8, 2023, 3:19 pm115 ptsPHYSorg
Myelotoxicity is the primary dose-limiting effect of the commonly used chemotherapeutic agent 5-fluorouracil (5-FU), which may endanger the life of the patient. Ribosome biogenesis is a key pathway regulating hematopoietic stem cells, and its disruption is deleterious to hematopoiesis. Treatment with 5-FU…
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